Newly Published Research Connects ME/CFS and Covid-19

Unique collaboration between Harvard, Johns Hopkins and citizen-scientist supported by Solve M.E.

August 2021–A comprehensive review of ME/CFS and Long Covid research published this week suggests that symptoms of both may be caused by redox imbalance, which is linked to inflammation and reduction of cellular energy production. [Redox imbalance occurs when oxidants and antioxidants in a cell are in a state of disequilibrium, which can lead to cell death and contribute to disease development.]

The article, “Redox Imbalance Links Covid-19 and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome,” was authored by Dr. Bindu Paul of Johns Hopkins, Marian Lemle,  citizen-scientist affiliated with Solve M.E., Dr. Anthony Komaroff of Harvard Medical School, and Dr. Solomon Snyder of Johns Hopkins. It was published by Proceedings of the National Academy of Sciences earlier this week.

Solve M.E. facilitated the research by connecting Lemle with her co-authors at Harvard and Johns Hopkins and by funding the project. The collaboration introduced award-winning researchers–Dr. Paul and Dr. Snyder–to ME/CFS, one of Solve’s strategic priorities. Lemle has long been interested in cellular energy production and ME/CFS, writing about it and presenting on it at IACFS/ME conferences and before Congress. 

The authors also explored several potential treatments for redox imbalance, including ubiquinol, glutathione, selenium and vitamins C, D and E and found that none demonstrated dramatic improvements in conditions associated with redox imbalance, yet provide a direction for future research. They concluded that studying redox imbalance in Long Covid and ME/CFS could lead to new diagnostics and therapies.